Primeadine® Gluten Free Spermidine Supplement - Oxford Healthspan

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1 bottle / 30 day supply
Buy 3 bottles and get 5% discount

Primeadine® GF is a wholly plant-derived, gluten-free spermidine supplement sourced and made in the longevity islands of Okinawa, Japan, home to some of the world's longest-lived people. A unique blend of 3 autophagy inducers - Okinawan chlorella, nobiletin from "Shikuwasa" citrus lime peel, and turmeric - it provides 1.2mg of plant-derived spermidine per serving.

What are the benefits?

  • Supports sleep quality
  • Promotes hair growth
  • Supports skin and nail health
  • Promotes energy and vitality
  • Supports memory, cognition, and brain health
  • Helps maintain gut health
  • Promotes hormonal balance
  • Mimics the benefits of fasting

 Check out the video below which also has testimonials and information. 
You can also click here to see reviews from Trustpilot.
Nadine Artemis, founder of Living Libations, talks with Leslie Kenny (founder of Primeadine) in the podcast below. 


Key Ingredients:

Primeadine® GF is made up of Okinawan Chlorella (Whole, Broken Cell Wall), Okinawan Shikuwasa (Citrus Depressa) Skin, and Okinawan Turmeric (Curcuma Longa) (Whole). This provides:

  • Spermidine - 1.2mg
  • Lutein - 2.35mg
  • Autophagy enhancer, nobiletin - 0.3mg
  • Naturally-occurring sources of vitamins & minerals: vitamin D2 (7mcg), vitamin K (6mcg), folate (25mcg), vitamin B12 (0.09mcg), biotin (3mcg), pantothenic acid (0.04mg), and iron (0.3mg).

Other ingredients: Tricalcium phosphate.

Please do not take it if you are allergic to chlorella, citrus, or turmeric.

Free from:

  • Gluten
  • Soy
  • Lactose
  • Synthetics
  • GMOs
  • Heavy Metals
  • Toxins
  • Fillers
  • Flow Agents
  • PUFAs

Primeadine® GF is made in an FDA-registered facility, in Okinawa, Japan, that does NOT handle wheat, shellfish, dairy, or nuts.

Okinawan Chlorella

Primeadine® GF derives its spermidine from a special sub-strain of chlorella from the longevity islands of Okinawa, Japan. This chlorella is cultivated in a pristine coastal setting using pure water from a volcanic, rock-filtered source in the mountains. We then rigorously examine it for heavy metals, mold, fungi, and bacteria at the Japan Food Research Lab (JFRL), a third-party testing facility.

To ensure optimal absorption, we employ a method that breaks the cell walls of chlorella, known as "broken cell wall chlorella".

Okinawan Shikuwasa (Citrus Depressa) Skin

Nobiletin, a powerful compound that triggers autophagy, is present in the peel of Okinawan citrus lime, known as "Shikuwasa." Shikuwasa is Japan's national lime and is a frequent feature in the diets of Okinawan centenarians. These long-lived individuals incorporate Shikuwasa into their daily routines by drinking Shikuwasa juice and using it to flavor marinades, sauces, and broths.

Okinawan Turmeric (Curcuma Longa)
The exceptional profile of vitamins and minerals found in Okinawan soil is a result of the unique combination of ancient coral rock and volcanic rock that makes up the island. This distinctive soil composition greatly enhances the potency of its turmeric. Turmeric, renowned for its strong anti-inflammatory properties, contains curcumin, which has also been discovered to activate autophagy.

How to Use

Serving size: 2 capsules per day, taken with liquid at mealtime.

For long term use:

We suggest taking Primeadine® with your last meal to kickstart autophagy before bed, or with your breakfast to extend the benefits of your overnight fast.

For first time use:

However, the first time you take it we recommend working up to the full daily dosage over 2 consecutive days.

Day 1: Take 1 capsule with liquid at mealtime.

Day 2: Take 2 capsules with liquid at mealtime.

  • Hemochromatosis: Due to the naturally-occurring iron content, please discuss with your healthcare practitioner before taking if you have this condition.
  • Please do not take it if you're allergic to chlorella, citrus, or turmeric. If you experience any negative effects or reactions, please discontinue use immediately.

What is Spermidine?

Spermidine is a naturally-occurring and potent polyamine (a kind of protein) known for inducing autophagy, the body's cellular renewal and recycling process. It also inhibits 9 of the 12 aging pathways, which are known as the "Hallmarks of Aging".

2/3 of the spermidine found in the human body is produced endogenously, or in the body, by the gut microbiota and various tissues. The final 1/3 is found exogenously, or externally, in the food that we eat. 

As we age, our body's ability to produce it declines. To restore youthful levels of spermidine, we have to look externally. Otherwise, our cells' ability to trigger autophagy will continue to decline and the aging pathways will progress.


Why is this Spermidine supplement more expensive that others on the market? 

  • We take great care to use the highest quality ingredients available and to keep out the 'nasties' commonly found in the supplement manufacturing process. We take the same approach that we do when baking a birthday cake for our children: we use the highest quality ingredients - no industrial seed oils such as wheat germ oil that oxidizes rapidly and wreaks havoc in our cells, no magnesium stearate to make the powder flow faster through automated encapsulation equipment (approximately 80% of all magnesium stearate used as 'flow agents' contain hydrogenated industrial seed oils), and no talc to make the powder denser and fit more compactly into fewer capsules. 
  • We also do not use synthetic spermidine, which is very cheap and often 'cut' into products stating they contain 'wheat germ with spermidine.'  
  • We choose food-derived spermidine, sourced and manufactured in Japan, which has one of the strictest food and supplement regulatory regimens in the world. Our products undergo rigorous third party lab testing to ensure they are of the purest and most effective quality. Yes, it is more costly, just as the best cake ingredients for your child's birthday cake would be too. It's a choice and philosophy we wholeheartedly believe in and follow every step of the way.



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